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Duphalac 10mg/15ml

Duphalac general information

What is Duphalac used for?

Duphalac solution is an oral liquid used to treat chronic constipation. It acts as a laxative, making the stools softer and easy to pass. It usually takes two to three days to be effective and relieve the blockage caused by constipation. Duphalac solution is also used to treat hepatic (portal-systemic) encephalopathy, which is a condition caused by liver failure that results in serious symptoms including, confusion and coma and can be fatal. Toxic substances that are normally removed by the liver accumulate in the blood, cross the blood/brain barrier and can cause impaired brain function. Duphalac solution used the same mechanism of action to relieve constipation and to remove toxic substances from the blood to prevent and treat hepatic encephalopathy.

How does Duphalac work?

Duphalac solution is an oral liquid that contains lactulose, which is a synthetic disaccharide (complex sugar molecule) and is used as an osmotic laxative to treat constipation. Lactulose in Duphalac solution passes through the intestines unchanged until it reaches the colon (large intestine), where it is broken down by a particular bacteria that metabolises sugars (sacchrolytic bacteria). The products of this bacterial metabolism are smaller molecules like organic acids, mainly lactic acid, which makes the contents of the colon more acidic and changes the osmotic pressure in the colon, so that water is drawn into the colon by osmosis. The increase in water content of the stools makes them softer and this increases the peristaltic activity of the colon, making the stools easier to pass. Hepatic encephalopathy a complication of liver disease is usually caused by a build up of substances like ammonia to levels that are toxic to the brain. Ammonia is produced as a by-product of protein metabolism by bacteria in the intestines and is usually eliminated by the liver. As Lactulose in Duphalac solution is metabolised, the increased acidity of the colon causes ammonia to be retained and the trapped excess ammonia is excreted in the stools, which is helped by the laxative effect of lactulose, resulting in a synergistic mechanism to remove ammonia, since the stools are not so readily available to the ammonia producing bacteria. This action helps to prevent the build-up of ammonia thereby reducing the amount of ammonia that enters the blood and relieving symptoms of hepatic encephalopathy.

What does Duphalac contain?

Duphalac solution contains the active ingredients lactulose (10mg/15ml), an osmotic laxative in an oral liquid (containing galactose and lactose 1.5mg/15ml each) that is used to treat constipation and also treat and prevent hepatic encephalopathy.

Treating constipation with Duphalac

Duphalac solution is an oral liquid that contains lactulose, which is an osmotic laxative used to treat chronic constipation. Lactulose in Duphalac solution passes through the intestines unchanged until it reaches the colon (large intestine), where it is broken down by a particular bacteria that metabolises sugars (sacchrolytic bacteria) and this produces smaller molecules like organic acids, mainly lactic acid. Metabolism of lactulose makes the contents of the colon more acidic and changes the osmotic pressure in the colon, so that water is drawn into the colon by osmosis. This increases the water content of the stools makes them softer, which increases the peristaltic activity of the colon, making the stools easier to pass. It usually takes two to three days to be effective and relieve the blockage caused by constipation.

Duphalac for hepatic encephalopathy

Duphalac solution is an oral liquid that contains lactulose, which is an osmotic laxative that is also used to treat hepatic (portal-systemic) encephalopathy, a complication of liver disease that is usually caused by a build up of substances like ammonia to levels that are toxic to the brain. Ammonia is produced as a by-product of protein metabolism by bacteria in the intestines and is usually eliminated by the liver. As a result of liver failure ammonia is not eliminated and serious symptoms of ammonia toxicity include, confusion and coma, and can be fatal. Lactulose in Duphalac solution passes through the intestines unchanged until it reaches the colon (large intestine), where it is broken down by a particular bacteria that metabolises sugars (sacchrolytic bacteria) and this produces smaller molecules like organic acids, mainly lactic acid, which makes the contents of the colon more acidic. Ammonia is retained in the colon and the trapped excess ammonia is excreted in the stools. This action helps to prevent the build-up of ammonia thereby reducing the amount of ammonia that enters the blood and relieving symptoms of hepatic encephalopathy.

What are the side effects of Duphalac?

The most commonly reported side effects when taking Duphalac include: abdominal discomfort or pain, flatulence (build up of wind), abdominal cramps, nausea, vomiting, diarrhoea.

When should Duphalac not be used?

You should not use Duphalac solution if you:
  • are allergic to lactulose or any ingredients in Duphalac
  • have galactosaemia a metabolic disorder caused by to inability to metabolise galactose in the diet
  • have disaccharide deficiency
  • are on a low galactose diets or a galactose and/or lactose free diet
  • have any form of bowel obstruction other than constipation
  • are breastfeeding without discussion with your doctor
  • have kidney or liver disease
  • are taking medicines that interact with Duphalac, including the antibiotic neomycin

How should Duphalac be taken?

You should take your Duphalac solution as a single dose for relief of constipation, usually after breakfast. The amount you take depends on your condition and should be as recommended by your doctor. Once your constipation has been relieved your dose may be reduced. For treatment of hepatic encephalopathy you should take your Duphalac solution with or without food, 3-4 times daily, or as recommended by your doctor, and your dose may be reduced. If you require a rapid laxative effect for treatment of hepatic encephalopathy your doctor may suggest hourly dosing initially, then reduced to 3-4 times daily. You should continue to take your Duphalac solution for as long as recommended by your doctor, which may be for long-term treatment.

How long should you take Duphalac?

You should continue to take your Duphalac solution for as long as recommended by your doctor, which may be for long-term treatment.

Missed dose of Duphalac

If you miss a dose of Duphalac solution take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Duphalac be stored?

You should store your Duphalac above 25°C, do not refrigerate or freeze.


Solvay PharmaceuticalsLaxative
USDInhousePharmacy.bizNewOut of Stock1Duphalac 10mg/15ml 1000ml/Bottle
Duphalac 10mg/15ml


Duphalac 10mg/15ml

Duphalac 10mg/15ml


Product Name
Duphalac 10mg/15ml 1000ml/Bottle
Active Ingredient
Lactulose
Manufacturer
Solvay Pharmaceuticals
Product Type
Laxative
Product expiry date we are currently shipping
Discontinued, no stock
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Duphalac contains lactulose, an osmotic laxative that is used to treat constipation and also treat and prevent hepatic encephalopathy.

Duphalac general information

What is Duphalac used for?

Duphalac solution is an oral liquid used to treat chronic constipation. It acts as a laxative, making the stools softer and easy to pass. It usually takes two to three days to be effective and relieve the blockage caused by constipation. Duphalac solution is also used to treat hepatic (portal-systemic) encephalopathy, which is a condition caused by liver failure that results in serious symptoms including, confusion and coma and can be fatal. Toxic substances that are normally removed by the liver accumulate in the blood, cross the blood/brain barrier and can cause impaired brain function. Duphalac solution used the same mechanism of action to relieve constipation and to remove toxic substances from the blood to prevent and treat hepatic encephalopathy.

How does Duphalac work?

Duphalac solution is an oral liquid that contains lactulose, which is a synthetic disaccharide (complex sugar molecule) and is used as an osmotic laxative to treat constipation. Lactulose in Duphalac solution passes through the intestines unchanged until it reaches the colon (large intestine), where it is broken down by a particular bacteria that metabolises sugars (sacchrolytic bacteria). The products of this bacterial metabolism are smaller molecules like organic acids, mainly lactic acid, which makes the contents of the colon more acidic and changes the osmotic pressure in the colon, so that water is drawn into the colon by osmosis. The increase in water content of the stools makes them softer and this increases the peristaltic activity of the colon, making the stools easier to pass. Hepatic encephalopathy a complication of liver disease is usually caused by a build up of substances like ammonia to levels that are toxic to the brain. Ammonia is produced as a by-product of protein metabolism by bacteria in the intestines and is usually eliminated by the liver. As Lactulose in Duphalac solution is metabolised, the increased acidity of the colon causes ammonia to be retained and the trapped excess ammonia is excreted in the stools, which is helped by the laxative effect of lactulose, resulting in a synergistic mechanism to remove ammonia, since the stools are not so readily available to the ammonia producing bacteria. This action helps to prevent the build-up of ammonia thereby reducing the amount of ammonia that enters the blood and relieving symptoms of hepatic encephalopathy.

What does Duphalac contain?

Duphalac solution contains the active ingredients lactulose (10mg/15ml), an osmotic laxative in an oral liquid (containing galactose and lactose 1.5mg/15ml each) that is used to treat constipation and also treat and prevent hepatic encephalopathy.

Treating constipation with Duphalac

Duphalac solution is an oral liquid that contains lactulose, which is an osmotic laxative used to treat chronic constipation. Lactulose in Duphalac solution passes through the intestines unchanged until it reaches the colon (large intestine), where it is broken down by a particular bacteria that metabolises sugars (sacchrolytic bacteria) and this produces smaller molecules like organic acids, mainly lactic acid. Metabolism of lactulose makes the contents of the colon more acidic and changes the osmotic pressure in the colon, so that water is drawn into the colon by osmosis. This increases the water content of the stools makes them softer, which increases the peristaltic activity of the colon, making the stools easier to pass. It usually takes two to three days to be effective and relieve the blockage caused by constipation.

Duphalac for hepatic encephalopathy

Duphalac solution is an oral liquid that contains lactulose, which is an osmotic laxative that is also used to treat hepatic (portal-systemic) encephalopathy, a complication of liver disease that is usually caused by a build up of substances like ammonia to levels that are toxic to the brain. Ammonia is produced as a by-product of protein metabolism by bacteria in the intestines and is usually eliminated by the liver. As a result of liver failure ammonia is not eliminated and serious symptoms of ammonia toxicity include, confusion and coma, and can be fatal. Lactulose in Duphalac solution passes through the intestines unchanged until it reaches the colon (large intestine), where it is broken down by a particular bacteria that metabolises sugars (sacchrolytic bacteria) and this produces smaller molecules like organic acids, mainly lactic acid, which makes the contents of the colon more acidic. Ammonia is retained in the colon and the trapped excess ammonia is excreted in the stools. This action helps to prevent the build-up of ammonia thereby reducing the amount of ammonia that enters the blood and relieving symptoms of hepatic encephalopathy.

What are the side effects of Duphalac?

The most commonly reported side effects when taking Duphalac include: abdominal discomfort or pain, flatulence (build up of wind), abdominal cramps, nausea, vomiting, diarrhoea.

When should Duphalac not be used?

You should not use Duphalac solution if you:
  • are allergic to lactulose or any ingredients in Duphalac
  • have galactosaemia a metabolic disorder caused by to inability to metabolise galactose in the diet
  • have disaccharide deficiency
  • are on a low galactose diets or a galactose and/or lactose free diet
  • have any form of bowel obstruction other than constipation
  • are breastfeeding without discussion with your doctor
  • have kidney or liver disease
  • are taking medicines that interact with Duphalac, including the antibiotic neomycin

How should Duphalac be taken?

You should take your Duphalac solution as a single dose for relief of constipation, usually after breakfast. The amount you take depends on your condition and should be as recommended by your doctor. Once your constipation has been relieved your dose may be reduced. For treatment of hepatic encephalopathy you should take your Duphalac solution with or without food, 3-4 times daily, or as recommended by your doctor, and your dose may be reduced. If you require a rapid laxative effect for treatment of hepatic encephalopathy your doctor may suggest hourly dosing initially, then reduced to 3-4 times daily. You should continue to take your Duphalac solution for as long as recommended by your doctor, which may be for long-term treatment.

How long should you take Duphalac?

You should continue to take your Duphalac solution for as long as recommended by your doctor, which may be for long-term treatment.

Missed dose of Duphalac

If you miss a dose of Duphalac solution take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Duphalac be stored?

You should store your Duphalac above 25°C, do not refrigerate or freeze.


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