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Spirotone 25, 100 Tablets/Pack


Spirotone 25, 100 Tablets/Pack

 

Spirotone 25 (Spironolactone)


Product Name
Spirotone 25, 100 Tablets/Pack
Also known as Aldactone
Active Ingredient
Spironolactone
Manufacturer
Pacific Pharmaceuticals
Product Type
Anti-Androgen diuretic
Product expiry date we are currently shipping
Discontinued, no stock
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This product has been discontinued, but we do have alternatives below.

Spirotone tablets 25mg contain spironolactone and are used to treat fluid retention (oedema) in patients with heart failure, high blood pressure, liver and kidney disease, hypokalaemia and hyperaldosteronism. They can also be used to help stimulate the development of female sexual characteristics in transgender hormone therapy.

Spirotone general information

What is Spirotone used for?

Spirotone tablets 25mg are used to reduce fluid retention and swelling (oedema) which is caused by several conditions, including congestive heart failure, hypertension (high blood pressure), liver cirrhosis and kidney disease. Spirotone 25 is also used to increase blood potassium levels, in a condition called hypokalaemia (low blood potassium) and to treat hyperaldosteronism, which is caused by excess secretion by the adrenal gland of the hormone aldosterone (involved in regulating sodium and potassium levels), both of which can cause fluid retention. Spirotone tablets 25mg has anti-androgen activity which is used in the treatment of female hirsutism (androgen-related increase in facial and body hair) and can be used as an anti-androgen component of transgender hormone therapy, to help stimulate the development of female sexual characteristics for male to female transsexuals. Other potential uses include treatment of hair loss and acne in women and male pattern baldness.

How does Spirotone work?

Spirotone tablets 25mg contain spironolactone, a potassium-sparing diuretic (water pill) that acts as an antagonist of the hormone aldosterone, blocking its action to increase sodium excretion and reduce potassium loss at the distal renal tubule of the kidney. The overall effect of this action is to increase water excretion in the urine which reduces fluid build up in the tissues, increases blood potassium levels and lowers blood pressure. Spironolactone in Spirotone 25 also has moderate anti-androgenic activity as it binds to the androgen receptor competing with dihydrotestosterone (DHT) an active metabolite of testosterone, which promotes male characteristics, and therefore blocking the action of DHT. Another anti-androgenic action of Spironolactone 25mg is that it blocks the synthesis of a testosterone by the ovaries.

What does Spirotone contain?

Spirotone tablets 25mg contain the active ingredient spironolactone, a potassium-sparing diuretic that is used to reduce fluid retention and swelling (oedema) caused by several conditions. They also contain quinoline yellow, sunset yellow, erythrosine, polysorbate, peppermint oil, povidone, microcrystalline cellulose, maize starch, sodium starch glycollate, talc, magnesium stearate and lactose.

Treating fluid retention with Spirotone

Spirotone tablets 25mg contain spironolactone, a potassium-sparing diuretic (water pill) that is used to treat fluid retention and swelling (oedema) caused by several conditions, including congestive heart failure, hypertension (high blood pressure), liver cirrhosis and kidney disease. Spironolactone in Spirotone tablets 25 causes the kidneys to excrete excess water and sodium from the body while at the same time maintaining blood potassium levels.

Treating low blood potassium with Spirotone

Spirotone tablets 25mg contain spironolactone, a potassium-sparing diuretic (water pill) is used to treat low blood potassium (hypokalaemia) by reducing the loss of potassium from the kidneys.

Treating hyperaldosteronism with Spirotone

Spirotone tablets 25mg contain spironolactone, a potassium-sparing diuretic (water pill) that is used to treat hyperaldosteronism, a condition caused by excess secretion by the adrenal gland of the hormone aldosterone, which is involved in regulating sodium and potassium levels. Excess aldosterone can cause an imbalance in sodium and potassium levels and result in fluid retention (oedema).

Spirotone for transgender treatment

Spirotone tablets 25mg contain spironolactone, which is primarily used as a diuretic, to reduce fluid retention in conditions such as congestive heart failure, hypertension (high blood pressure), liver cirrhosis and kidney disease. Another action of spironolactone is that it acts as an anti-androgen by binding to the androgen receptor and competing with dihydrotestosterone (DHT) an active metabolite of testosterone, which promotes male characteristics, and therefore blocking the action of DHT. Using an anti-androgen like spironolactone (usually in high doses of 200–400 mg per day) allows the amount of oestrogen administered for feminising hormone therapy to be reduced while optimising the hormone regime needed to stimulate breast development, feminisation of skin, and female fat distribution.

What are the side effects of Spirotone?

Although not everyone will experience side effects from taking Spirotone tablets 25mg, there are some that are more common, such as nausea, vomiting, headache, abdominal cramps and pain, diarrhoea, headache, drowsiness, lethargy and skin rash. Other side effects include menstrual period changes in women, and breast enlargement (gynaecomastia) and sexual problems (impotence) in men

When should Spirotone not be used?

You should not use Spirotone tablets 25mg if you:
  • are pregnant, planning to become pregnant, or breast-feeding
  • are allergic to spironolactone or any other ingredients in Spirotone 25
  • have kidney or liver problems
  • have high potassium levels in your blood
  • are not producing or passing urine
  • are taking other medications that may interact with Spirotone, such as potassium supplements, non-steroidal anti-inflammatory drugs like indomethacin or mefenamic acid, aspirin, digoxin for heart failure, carbenoxolone for mouth ulcers, other diuretics, antihypertensives (ACE inhibitors), steroids such as prednisone

How should Spirotone be taken?

You should take Spirotone tablets 25mg with a glass of water with or without food, once or twice daily. The dose you take depends on your condition and should be as recommended by your doctor. You should continue taking your tablets even if you are feeling well, which may be for a few days or several weeks and your doctor may increase your dose during treatment.

How long should you take Spirotone?

You should take Spirotone tablets 25mg for as long as is recommended by your doctor, which may be for a few days or several weeks and you should continue taking your tablets even if you are feeling well.

Missed dose of Spirotone

If you miss a dose of Spirotone 25mg tablets take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Spirotone be stored?

You should store your Spirotone 25mg tablets below 30°C and avoid exposure to heat, light and moisture.


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